The gameplay is typical Roguelike, although the sci-fi elements mark a nice change from the usual dungeon romp. "Roll" your character to determine starting stats, then send him/her off into the complex. As your character battles 24 types of building employees and gains experience, his/her attributes will increase. Instead of chests, you will open "files," and instead of spells you will "use strategies," which can be found in the Library at the start of each game. The results of these strategies (which range from "Bluff" to "Flatter" and "Hypnotize") are often fun to watch.

In addition to the straightforward gameplay, there are also some tricks that you wouldn't find in other Roguelikes - some more annoying than fun. For instance, once in a while all the lights will go out and you will not be able to see at all. The only way to proceed is to light a match (obtained from employees you defeated) and fight the fuse box to turn the lights back on. But in general, though, Mission: Mainframe is a decent and fun Roguelike, although more weapon and enemy types as well as more unique floor designs (they all look the same after a while, just with different enemies) would have been nice. Recommended, although not a Top Dog.